This case study describes the Nuestra Casa (Our House) Initiative, an advocacy, communication, and social mobilization strategy to increase tuberculosis (TB) awareness through a public art exhibition hosted at the University of Texas at El Paso. This work describes this multi-disciplinary initiative that cut across academic boundaries to engage faculty, students, and community members in service-learning and community engagement efforts. Nuestra Casa reached diverse audiences, including school children, farm workers, promotoras (health promoters), university students, educators, persons affected by TB, and public health officials in Mexico and in the United States through education, critical reflection, and a call to action.